Potential of Osthole as Alternative Medicine in Alzheimer Disease

Alzheimer disease (AD) is a complex neurodegenerative disease that leads to the decline in the cognition in elderly people (>65 years of age). Deposition of senile plaques (of amyloid β) and neurofibrillary tangles (of hyperphosphorylated tau) are the typical hallmarks of the disease. AD significantly contributes to the worldwide dementia, which is 46.8 million in 2015 and estimated to 131.5 million in 2050. A better understanding of the pathology and early diagnosis is needed to delay or prevent AD [1,2].